Remark: Barbiturates might improve adverse effects, like respiratory depression, made by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs. pentobarbital will lessen the extent or impact of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration o... https://arthurvoevk.onesmablog.com/nembutal-pentobarbital-options-74905825