Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators with the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have determined recurrent mutations in genes regulating tumor mobile-microenvironment interactions, wh... https://roberta009lbp5.wikilentillas.com/user