Chemotherapy was potentiated by E7449 and single agent had considerable antitumor activity in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, probably by way of TNKS inhibition. In line with this risk, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and considerably altered expression https://yoda199876.blogrelation.com/35366589/the-basic-principles-of-lumacaftor